BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CBRNE Central - ECPv6.18.2//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:CBRNE Central
X-ORIGINAL-URL:https://cbrnecentral.com
X-WR-CALDESC:Events for CBRNE Central
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20220313T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20221106T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20230312T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20231105T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20231207T130000
DTEND;TZID=America/New_York:20231207T140000
DTSTAMP:20231128T232455Z
CREATED:20231128T232455Z
LAST-MODIFIED:20231128T232455Z
UID:27989-1701954000-1701957600@cbrnecentral.com
SUMMARY:Validation of a Confirmatory Proteomic Mass Spectrometry Body Fluid Assay
DESCRIPTION:The NIJ Forensic Technology Center of Excellence will host a forensic training event on Validation of a Confirmatory Proteomic Mass Spectrometry Body Fluid Assay on 30 November 2023 via webinar. \nWith increasingly sensitive forensic methods for DNA detection\, the source from which a DNA profile is obtained becomes increasingly important. Was an individual’s DNA identified at a crime scene from blood\, saliva\, semen\, or from a touched object? Knowledge of the source of DNA can add important contextual information to investigations as well as evidence presented at trials. Currently\, nearly all serology (body fluid) testing is presumptive\, meaning the results are not definitive\, and consequently do not carry the same scientific and statistical weight as forensic DNA analysis does.  \nTo address this issue\, the New York City Office of Chief Medical Examiner (NYC OCME) has developed a confirmatory assay for the identification of blood\, saliva\, and semen using proteins as body fluid markers. Because different body fluids have different functions\, they express different proteins that are specific to those functions. For example\, in blood the protein hemoglobin carries oxygen\, in saliva the protein amylase aids in digestion\, and in semen the protein semenogelin functions in reproduction. The presence of these marker proteins\, as well as other blood\, saliva\, and semen marker proteins\, can be used to distinguish one body fluid from another. However\, in addition to identifying multiple specific markers in each body fluid\, an assay must also employ methods that confirm that the markers are actually there. To achieve this\, we use mass spectrometry to effectively determine the amino acid sequences of each protein marker\, thus confirming their presence in a sample. \nThe assay developed at the NYC OCME uses multiple protein markers for each body fluid. The assay is unbiased\, i.e. there is no a priori guessing about what a body fluid might be on a piece of evidence – all samples are treated alike from extraction through analysis\, and all body fluid markers are simultaneously checked in each sample. The assay can identify mixtures and determine species. Finally\, the assay is fast and inexpensive – mass spectrometers are already found in toxicology laboratories. The NYC OCME Molecular Serology Assay has been accredited by ANAB and approved by the New York State Commission on Forensic Science. \nDetailed Learning Objectives\n\nAttendees will gain an understanding of the importance of\, and difference between\, presumptive and confirmatory tests.   \nAttendees will learn how and why specific body fluid marker proteins were selected.  \nAttendees will learn why multiple reaction monitoring (MRM) mass spectrometry is a confirmatory test. \n\nPlease visit the NIJ Forensic Technology COE’s Validation of a Confirmatory Proteomic Mass Spectrometry Body Fluid Assay event website to register. \n 
URL:https://cbrnecentral.com/event/validation-of-a-confirmatory-proteomic-mass-spectrometry-body-fluid-assay/
CATEGORIES:Training,Webcast-Remote
ORGANIZER;CN="Forensic Technology Center of Excellence":MAILTO:forensicCOE@rti.org
LOCATION:
END:VEVENT
END:VCALENDAR